medicine
Kinases are a large family of enzymes that play crucial roles in cellular functions through phosphorylation, impacting various processes such as cell metabolism, signaling, and transport. Due to their significant roles in human physiology and the potential for mutations to cause diseases like cancer, kinases have emerged as important targets for drug discovery.
At Creative Biogene, we offer a comprehensive collection of Kinase Stable Cell Lines. These cell lines are designed for in vitro cell-based kinase assays, enabling researchers to streamline their studies involving kinase activity and its implications in various diseases.
Key Features of Our Kinase Stable Cell Lines:
- Long-Term Expression: Exogenous fragments can be stably expressed in dividing cells for extended periods.
- Verified Clones: Selected clones are confirmed by PCR sequencing and Western blot analysis to ensure reliability.
- High Sensitivity: Our cell lines provide exceptional assay sensitivity and reproducibility.
- Proliferation Assays: Performance on proliferation assays using corresponding inhibitors ensures consistent results.
Applications
The applications of our kinase stable cell lines are extensive, including:
- Studying Mutation Effects: Analyze the impact of kinase mutations on downstream signaling and cellular processes.
- High-Throughput Screening: Efficiently screen small molecule kinase inhibitors at the cellular level.
- Therapeutic Strategies: Identify new strategies targeting kinases and their mutations in cancer therapies.
- Resistance Mechanism Studies: Develop models to understand resistance to small molecule inhibitors and test innovative combination therapies.
- Biomarker Potential: Assess the viability of kinases as diagnostic and prognostic markers for specific cancers.
Conclusion
The kinases stable cell lines available through Creative Biogene enable significant advancements in cancer research and drug development. With a robust selection and proven methodologies, these cell lines serve as essential tools for understanding kinase functionality and therapeutic targeting.
For more information or to explore our offerings in detail, visit our page on Kinase Stable Cell Lines.